Vibrios

Bugs

a disease of the poor and the third world, especially with indigenous populations
need high infectous count/dose for disease
bacteria usually hate acid, and survive better if stomach is alkaline
antagonists which decrease stomach acid increases susceptibility to all enteric pathogens
food has a buffering effect making the stomach vulnerable to bacteria
death is caused by dehydration
Cholera beds have a hole for your buns with a bucket underneath
- The goal is to allow bowel movements with "fire-hose diarrhoea" (not really stool; looks more like clear, foamy malodourous water)
enterotoxin activated adenylate cyclase system
cannot hydrolyse GTP → GDP
constantly activated
produces too much cAMP and causes hypersecretion of water and electrolytes, which results in secretory diarrhoea (important)

Salt-loving
commonly present in raw and undercooked shellfish.
Common cause of GI problem in Japan due to the large consumption of sashimi (raw fish)
Releases enterotoxin
Also, raw oysters in New Orleans cause Vibrios parahaemolyticus infections.

aka monster of the deep
Salt-loving, so salt as a disinfectant is not useful
invasive, aggressive, causes fatal generalized sepsis
Need immediate IV antibiotics
Associated with sea water exposure (raw seafood/swimming in the sea)
if a necrotic ulcer occurs after a history of exposure to sea water, give IV antibiotics immediately
Vibrios vulnificus is killed by chlorine, so it is not a problem in public swimming pools