Hyperlipidemia

From IKE

Targets

Risk	10-year CAD Risk	Recommendations	Grade, LOE
High	≥20%	Treatment targets: Primary: LDL-C <2.0 mmol/L Secondary: TC/HDL-C <4.0	Class I, level A Class IIa, level A
Moderate	10% – 19%	Treat when: LDL-C ≥3.5 mmol/L or TC/HDL-C ≥5.0	Class I, level A Class I, level A
Low	<10%	Treat when: LDL-C ≥5.0 mmol/L or TC/HDL-C ≥6.0	Class IIa, level A Class IIa, level A

Screening

• M> 40; F >50 (or postmenopausal): Full lipid profile q1-3y
• Children if FH of monogenic lipid disorder (familial hypercholesterolemia or chylomicronemia)
• DM
• Smoker
• HTN
• Waist circumference > 102cm (M); 88cm (F)
• FH of premature CAD (M < 55; F < 65)
• Manifestation of hyperlipidemia
• Exertional chest discomfort, dyspnea, erectile dysfunction
• Chronic kidney disease
• Lupus
• Evidence of Atherosclerosis